There are a number of investigator-initiated studies related to Mallinckrodt products in varying stages of completion. The following studies are listed on www.clinicaltrials.gov. Click on the links provided below to learn more.
A Pilot Study of Acthar as an Anti-Fibrotic Agent in Patients 1-Year Post Renal Transplantation
A Single Site, Investigator Initiated, Open Label, Observational Study on the Use of Acthar in Adult Onset Still's Disease
ACTH as a Re-Emerging Therapy for Uveitis (The ACTHAR Study)
ACTH as Treatment for Intractable Chronic Migraine
ACTH for Acute Treatment of Rheumatoid Arthritis Patients with Inadequate Response to Methotrexate
ACTH for Cutaneous Sarcoidosis Open Label Study
ACTH for Frequently Relapsing and Steroid Dependent Nephrotic Syndrome in Children
ACTH for Sarcoidosis-associated Calcium Dysregulation: Pilot Study
ACTH Treatment of APOL1-Associated Nephropathy
Acthar as Rescue Therapy for Transplant Glomerulopathy (TG) in Kidney Transplant Recipients
Acthar Dermatomyositis and Polymyosities Treatment (ADAPT Registry)
Acthar Effects on Myelination in Multiple Sclerosis Patients
Acthar Exposure and Outcomes Study in Adult Patients with Nephrotic Syndrome
Acthar for the Management of Treatment Resistant Nephrotic Syndrome in Children - A Pilot Study
Acthar in Rheumatoid Arthritis, Histologic and Functional Effect on Synovium
Acthar in the Treatment of Lupus Nephritis
Acthar Therapy for Severe CNS Sarcoidosis
Adrenocorticotropic Hormone (ACTH) for the Treatment of Sarcoid Uveitis
An Open Label, Multi-centered, Randomized Phase 2 Study to Evaluate the Safety, TolerabiLity and Bioactivity of Subcutaneous ACTH Gel in Patients with Scleritis: The ATLAS Study
An Open-Label Pilot Study of ACTH in the Treatment of IgA Nephropathy at High Risk of Progression
Analysis of Relapse in Multiple Sclerosis
Biomarkers to Characterize Subtypes of Neuroinflammation in Infantile Spasms and Responsiveness to ACTH
BRIGHT-MS Study: Utility of ADC Maps in Patients with Acute Demyelinating Lesions
Clinical and Electroencephalographic Treatment and Outcome Biomarkers in ACTH Treated Patients with Infantile Spasms
Clinical Efficacy of Acthar in Severe Dry Eye Patients
Clinical Impact of Acthar in the Psoriatic Arthritis Patient
Cognitive Relapse in Multiple Sclerosis
Cytokine Profile Before and After Acthar Treatment for Chronic Sarcoidosis
Defining the Functional and Neuro-protective Potential of Acthar in Acute Optic Neuritis
Effect of ACTH on Interactions Between Antigen Presenting Cells and CD4 Tcells - Relapsing Remitting MS
Effect of ACTH on Measures of Fatigue in Patients with Relapsing Multiple Sclerosis
Effect of Acthar Therapy on Residual Renal Function in Dialysis Patients
Efficacy of Acthar in Recurrent Focal Segmental Glomerusclerosis after Kidney Transplant
Establishing a National Pediatric Glomerular Disease Learning Health System
Experience with H.P. Acthar® Gel for Treatment of Patients with Nephrotic Syndrome Due to Various Etiologies and Its Effects on Podocyte Function
Exploring the Immunoregulatory Functions of Melanocortins
Glomerularnephritis Biopsy Registry
Mechanism of Action of Acthar Gel on Sarcoidosis Granulomas in a Novel Ex Vivo Model
Melanocortin Receptor Profiling in Dermatomyositis
MS Connect App: An Interactive Platform Connecting Physicians and Patients to Better Manage Multiple Sclerosis, Identify Relapses, and Improve Patient Quality of Life
Multiple Sclerosis Relapse Patients Who Failed Recovery After High Dose IV Methylprednisolone
Ocular Sarcoidosis: Open Label Trial of Acthar Gel
Open Label Proof of Concept Study to Evaluate Efficacy and Safety of ACTH Gel in Refractory DM/PM
Phase 4 Trial of Neuroprotection with ACTH in Acute Optic Neuritis
Pilot Trial of ACTH 14 Days vs 5 Days Multiple Sclerosis Relapse
Practice Patterns and Outcomes of Acthar use in Children with Nephrotic Syndrome
Registry for Advanced Sarcoidosis
Safety and Efficacy of Acthar Gel in Outpatient Dialysis Population
Tolerability of ACTH for Multiple Sclerosis Relapses
Treatment of Aggressive Forms of Multiple Sclerosis with Pulsed ACTH
Treatment of Chronic Antibody-Mediated Rejection in Kidney Transplant with Acthar
Use of ACTH in RA Related Flares
Use of Acthar in CKD Stage V or ESRD Patients in Preparation for a Kidney Transplant
Use of CXCL9 as a Biomarker of Acthar Efficacy
Utilizing Magnetoencephalography (MEG) to Improve Outcomes for Infantile Spasms
Whole Exome Sequencing and ACTH Responsiveness in Infantile Spasms
Dynamic Assessment Of Right Ventricular Function With Inhaled Nitric Oxide During Cardiac MRI
Effect of Nitric Oxide on Therapeutic Potential of Umbilical Cord Derived Mesenchymal Stem Cells (UC-Mscs)
Effect of Nitric Oxide on Key Hox Transcription Factor Proteins During ELBW O2-Induced Lung Injury
Exercising Capacity and Gas Exchange in Adults with a History of Bronchopulmonary Dysplasia
Improvement in Acute Respiratory Parameters in Preterm Infants Under 34 Weeks Gestation after Initiation of INO in the Setting of Hypoxemic Respiratory Failure
Inhaled Nitric Oxide after Out-Of-Hospital Cardiac Arrest
Inhaled Nitric Oxide and Brain Outcomes after Pediatric Traumatic Brian Injury
Inhaled Nitric Oxide and Hypoxic Brain Injury in the Newborn
Inhaled Nitric Oxide And Neuroprotection In Premature Infants
Inhaled NO In Pulmonary Embolism, A Randomized, Double Blind, Placebo Controlled Study
Potential Use Of Inhaled Nitric Oxide (Ino) As An Adjunct To Neonatal Resuscitation Protocol
Retrospective Data Review for Evaluation of Safety Profile of Terlipressin Usage in Single Centre Tertiary PICU in England
Terlipressin in the Treatment of Type-1 Hepatorenal Syndrome: Role of Inflammation in Disease Severity and Factors Associated with Response to Therapy
Effect of New Cellex Photopheresis System on the Cellular Immunity in CTCL Patients
Mechanism of Action and Involvement of Tregs Differs in ECP-Treated CTCL and GvHD Patients
T-Regulatory Subsets as a Predictor of Response GvHD Treated with ECP
Management of Acute and Chronic Graft-Versus-Host Disease with Extracorporeal Photopheresis (ECP). The Helsinki experience.
OL Prospective Study of Response to ECP and Role of Regulatory B Cells in cGvHD
Registry of the Therapeutic Impact and Quality of Life of Patients with Graft Versus Host Disease Undergoing Extracorporeal Photopheresis